No, caffeine doesn't appear to cause breast cysts (fibrocystic breast changes), a noncancerous (benign) breast disease. Anecdotally, some women report that breast pain symptoms improve when they go off caffeine or reduce the amount of caffeine in their diets. Jul 19, - Benign (pronounced bee-nine) breast cysts, also called fibrocystic condition, occur when breast cells retain fluid and develop small sacs. Coffee has been targeted as a potential cause of benign breast cysts specifically because of its caffeine content. However, the caffeine theory has not been proven scientifically.